July 21, 2025

Potential diagnostic markers and therapeutic targets for major depressive disorder based on bioinformatics analysis and Molecular Docking Studies

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Authors

BVBasavaraj VastradAl-Ameen College of Pharmacy SPShivaling PattanashettiNational Institute of Pharmaceutical Education and Research CVChanabasayya VastradSri Dharmasthala Manjunatheshwara College of Dental Sciences & Hospital

Discussion

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Implication

Bioinformatics analysis identifies key genes, microRNAs, and transcription factors in major depressive disorder, suggesting potential therapeutic targets.

Key Points

Core finding indicates that specific genes, microRNAs, and transcription factors may influence major depressive disorder.
A total of 958 differentially expressed genes were identified, highlighting potential diagnostic markers and therapeutic targets.
Gene ontology and pathway analyses showed enrichment in areas like cell communication and neuronal systems.
Molecular docking revealed key active compounds with promising binding activities to hub genes connected to major depressive disorder.

Cite This Study

Vastrad et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd234 https://doi.org/10.21203/rs.3.rs-7126770/v1

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Implication

Bioinformatics analysis identifies key genes, microRNAs, and transcription factors in major depressive disorder, suggesting potential therapeutic targets.