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July 21, 2025Brain SciencesOpen Access

Neurobiology of Dystonia: Review of Genetics, Animal Models, and Neuroimaging

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Authors

JRJamir Pitton RissardoAMAndrew McGarryYSYiwen Shi

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Overview

Review synthesizes findings on dystonia from genetics and neuroimaging, highlighting gaps in animal models.

Key Points

  • Dystonia involves over 400 identified genes, with about 76.6% linked to neurodevelopmental disorders.
  • The genetic diagnostic yield for dystonia remains low, ranging between 12% and 36%.
  • Challenges in developing effective animal models of dystonia affect the generalization of research findings.
  • Advances in neuroimaging have enhanced understanding of dystonia-related brain networks, necessitating future studies.

Cite This Study

Rissardo et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd3bfhttps://doi.org/10.3390/brainsci15070767
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