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June 13, 2026Current Opinion in Neurology

Dystonia: from phenotypes to genetics and therapeutic advances

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Authors

HCHan‐Lin ChiangYKYih-Chih KuoCLC Y Lin

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Overview

Review highlights advances in genetics and treatment for dystonia, suggesting pathways for enhanced patient care.

Key Points

  • The review aims to summarize recent advancements in dystonia classification, genetics, and therapeutic options.
  • Updated clinical classification systems and diagnostic algorithms were highlighted.
  • Emerging insights into neuronal dysfunction and molecular mechanisms were discussed.
  • Current treatment strategies, including pharmacological therapies and neuromodulation, were reviewed.
  • Recent advances identified multiple causative genes associated with dystonia.
  • Mechanism-based therapies are currently limited despite genetic insights.
  • A precise diagnostic framework was proposed to enhance patient stratification.

Cite This Study

Chiang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf528faef96ed7f05748dhttps://doi.org/10.1097/wco.0000000000001503
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neurobiology of Dystonia: Review of Genetics, Animal Models, and Neuroimaging2025 · 4 citations
  2. 2Genetic Update and Treatment for Dystonia2024 · 21 citations
  3. 3Dissecting genetic architecture of rare dystonia: genetic, molecular and clinical insights2024 · 17 citations
  4. 4A narrative review: clinical trials in therapeutic interventions for dystonia (2020 - 2025)2025
  5. 5Adult-onset Isolated Focal Dystonia: A Comprehensive Review of the Literature2026