Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 21, 2025

Structure-guided design of a novel, stable, and soluble Cecropin A variant for antimicrobial therapeutic applications

View Full Paper
Ask AI
Bookmark
Share

Authors

SHSamaneh HashemiShiraz University of Medical SciencesAZArmin ZareiKermanshah University of Medical SciencesMTMohammad Sadegh TaghizadehShiraz University

Discussion

Loading...

Member takes

Overview

Engineered peptide improves stability and solubility for enhanced antimicrobial applications, indicating potential for mucosal delivery.

Key Points

  • Pep A is a novel cecropin a variant with improved solubility and stability for therapeutic use.
  • The incorporation of an M cell-targeting peptide at the N-terminus enhances its antimicrobial action.
  • Computational modeling confirmed the structural integrity of Pep A, with superior folding characteristics.
  • High solubility allows for large-scale production, reinforcing Pep A's promise in advanced antimicrobial applications.

Cite This Study

Hashemi et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd53chttps://doi.org/10.21203/rs.3.rs-6996527/v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GalaxyRefine: protein structure refinement driven by side-chain repacking2013 · 1,417 citations
  2. 2Applying RSM for optimization of Ferula assafoetida protein hydrolysis to enhance bioactivity and functional properties2025 · 28 citations
  3. 3In Vitro Solubility Assays in Drug Discovery2008 · 123 citations
  4. 4Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination2012 · 99 citations
  5. 5The M Cell-Targeting Ligand Promotes Antigen Delivery and Induces Antigen-Specific Immune Responses in Mucosal Vaccination2010 · 133 citations