July 22, 2025Open Access

Associations between cannabis use, tobacco use and co-use with brain volume: a systematic review and meta-analysis

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Authors

KSKatherine SawyerKing's College London TFTom P. FreemanCentre for Addiction and Mental Health MSMartine SkumlienCentre for Addiction and Mental Health

Discussion

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Implication

Systematic review and meta-analysis reveal cannabis and tobacco use are linked to reduced brain volume in key regions, indicating potential neurological risks.

Key Points

Cannabis use is linked to smaller amygdala volumes compared to controls, suggesting possible neurobiological effects.
Tobacco users show decreased volumes in the amygdala, insula, pallidum, and total grey matter compared to non-users.
Meta-analyses involve data from 103 studies, with varied exposure and study designs focused on brain volume.
Findings highlight the necessity for further research into the neurological implications of cannabis and tobacco co-use.

Cite This Study

Sawyer et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd6da https://doi.org/10.1101/2025.07.21.25331928

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Implication

Systematic review and meta-analysis reveal cannabis and tobacco use are linked to reduced brain volume in key regions, indicating potential neurological risks.

Associations between cannabis use, tobacco use and co-use with brain volume: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Associations between cannabis use, tobacco use and co-use with brain volume: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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