What question did this study set out to answer?

The research aims to examine the relationship between cannabis and tobacco use and brain volume specifically focusing on key brain regions.

March 21, 2026AddictionOpen Access

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

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Systematic review finds cannabis and tobacco use affects brain volume, suggesting possible neurological implications.

The research aims to examine the relationship between cannabis and tobacco use and brain volume specifically focusing on key brain regions.
Conducted a systematic review and meta-analysis of existing literature.
Analyzed studies measuring brain volume in relation to cannabis and tobacco usage.
Identified specific brain regions impacted by substance use.
Cannabis use is linked to a smaller volume in the amygdala.
Tobacco use is associated with reduced volumes in the amygdala, insula, pallidum, and total grey matter.

Sawyer et al. (2026) studied this question.

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