Figure 2 from Plasma Cell-Free Human Papillomavirus DNA and Oral Gargle HPV DNA in Patients with HPV-Related Oropharyngeal Cancer Treated with Radiotherapy

Dynamic changes of plasma cfHPV DNA and its association with reduction of TTV at week 4. A, Plasma cfHPV DNA kinetics before, during, and after definitive radiation treatment. Each colored line represents a patient. Colors of lines represent patients who did (red) and did not (blue) have confirmed disease progression at 24 months. B, A box plot showing the % reduction of TTV at week 4 for patients who did or did not achieve plasma cfHPV DNA clearance at week 4. Positive (i.e., >0) numbers represent tumor volume reduction, whereas negative (i.e., <0) numbers represent tumor volume increase. Statistical test represents the Mann–Whitney test between the two groups overlaid by the bolded line. The median and upper and lower quartiles are represented in the bar graphs.