Combining enzymes with transition metal catalysts allows engineered cells to produce bioactive products, indicating a novel metabolic approach.
Exogenous transition metal catalysts can be combined with natural enzymes to perform designed, non-natural tandem reactions within living mammalian cells. The resulting abiotic metabolic network can process exogenous substrates to yield fluorescent or bioactive products, only in those cells that harness both catalytic systems.
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Vale-Gómez et al. (2025) studied this question.
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