Supplementary Figure 5 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Rona Yaeger; Riccardo Mezzadra; Jenna Sinopoli; Yu Bian; Michelangelo Marasco; Esther Kaplun; Yijun Gao; HuiYong Zhao; Arnaud Da Cruz Paula; Yingjie Zhu; Almudena Chaves Perez; Kalyani Chadalavada; Edison Tse; Sudhir Chowdhry; Sydney Bowker; Qing Chang; Besnik Qeriqi; Britta Weigelt; Gouri J. Nanjangud; Michael F. Berger; Hirak Der‐Torossian; Kenna Anderes; Nicholas D. Socci; Jinru Shia; Gregory J. Riely; Yonina R. Murciano‐Goroff; Bob T. Li; James G. Christensen; Jorge S. Reis‐Filho; David B. Solit; Elisa de Stanchina; Scott W. Lowe; Neal Rosen; Sandra Misale

doi:10.1158/2159-8290.29619024

Key Points

Kras g12c and egfr inhibitors face resistance challenges in colorectal cancer treatment.
Baseline alterations were identified in colorectal cancer patients who developed resistance to inhibitors.
An oncoprint visualization effectively displays genetic changes associated with resistance mechanisms.
Understanding resistance patterns can inform better therapeutic approaches for colorectal cancer patients.

Implication

Oncoprint highlights baseline alterations related to kras g12c and egfr resistance in colorectal cancer patients, suggesting implications for treatment strategies.

Abstract

Oncoprint of baseline alterations in CRC patients who developed resistance to KRAS G12C and EGFR inhibitors

Discussion

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Cite This Study

Yaeger et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd934 https://doi.org/10.1158/2159-8290.29619024

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Supplementary Figure 5 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 5 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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