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July 22, 2025

Supplementary Figure 6 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Rona Yaeger Riccardo Mezzadra Jenna Sinopoli Yu Bian Michelangelo Marasco Esther Kaplun Yijun Gao HuiYong Zhao Arnaud Da Cruz Paula Yingjie Zhu Almudena Chaves Perez Kalyani Chadalavada Edison Tse Sudhir Chowdhry Sydney Bowker Qing Chang Besnik Qeriqi Britta Weigelt Gouri J. Nanjangud Michael F. Berger Hirak Der‐Torossian Kenna Anderes Nicholas D. Socci Jinru Shia Gregory J. Riely Yonina R. Murciano‐Goroff Bob T. Li James G. Christensen Jorge S. Reis‐Filho David B. Solit Elisa de Stanchina Scott W. Lowe Neal Rosen Sandra Misale

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Key Points

Main finding shows acquired resistance mechanisms to KRASG12C-EGFR inhibition in colorectal cancer.
Key evidence demonstrates drug withdrawal responses in resistant cells, indicating the importance of treatment strategies.
Approach involves analyzing patient data and cell line models to understand resistance patterns.
Significance lies in improving therapeutic strategies for colorectal cancer patients with KRASG12C mutations.

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Implication

Supplementary figure details drug withdrawal effects in KRASG12C resistant cells, highlighting patient data insights.

Abstract

C106 resistant cells drug withdrawal and Patient #12 MSK-Impact data

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Cite This Study

Yaeger et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd946 https://doi.org/10.1158/2159-8290.29619021

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from Molecular Characterization of Acquired Resistance to KRAS<sup>G12C</sup>–EGFR Inhibition in Colorectal Cancer2025
2Supplementary Figure 1 from Molecular Characterization of Acquired Resistance to KRAS<sup>G12C</sup>–EGFR Inhibition in Colorectal Cancer2025
3Supplementary Figure 5 from Molecular Characterization of Acquired Resistance to KRAS<sup>G12C</sup>–EGFR Inhibition in Colorectal Cancer2025
4Supplementary Figure 4 from Molecular Characterization of Acquired Resistance to KRAS<sup>G12C</sup>–EGFR Inhibition in Colorectal Cancer2025
5Supplementary Figure S7 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024