Supplementary Figure 2 from Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Key Points

• MAIN FINDING: Acquired resistance mechanisms to KRAS-G12C-EGFR inhibition are characterized in colorectal cancer cell lines.
• KEY EVIDENCE: Single cell sequencing analysis provides detailed insights into resistance pathways.
• APPROACH: C106 cell lines underwent rigorous molecular characterization through single cell sequencing.
• SIGNIFICANCE: Understanding these resistance mechanisms could guide more effective therapies for colorectal cancer.