July 23, 2025Open Access

A mismatch between slow protein synthesis and fast environmental fluctuations determines tradeoffs in bacterial proteome allocation strategies

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Authors

JCJonas CremerStanford University LPL. Fernández-Cruz PérezHospital Clínic de Barcelona

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Overview

Model demonstrates how faster environmental fluctuations impact protein synthesis in bacteria, suggesting implications for antibiotic resistance and microbial ecology.

Key Points

The study reveals that a mismatch between rapid environmental changes and slow protein synthesis influences bacterial survival strategies.
Data shows that bacteria gain a growth advantage by pre-synthesizing resistance proteins before encountering antibiotics.
A mechanistic model integrates antibiotic kinetics with dynamic proteome allocation, highlighting acclimation in fluctuating environments.
Findings suggest that the benefits of anticipation in protein synthesis are amplified in environments with multiple antibiotic stresses.

Cite This Study

Cremer et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdb8e https://doi.org/10.1101/2025.07.22.666192

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July 23, 2025Open Access

A mismatch between slow protein synthesis and fast environmental fluctuations determines tradeoffs in bacterial proteome allocation strategies

View Full Paper

Ask AI

Bookmark

Authors

JCJonas CremerStanford University LPL. Fernández-Cruz PérezHospital Clínic de Barcelona

Discussion

Member takes

Overview

Model demonstrates how faster environmental fluctuations impact protein synthesis in bacteria, suggesting implications for antibiotic resistance and microbial ecology.

Key Points

The study reveals that a mismatch between rapid environmental changes and slow protein synthesis influences bacterial survival strategies.
Data shows that bacteria gain a growth advantage by pre-synthesizing resistance proteins before encountering antibiotics.
A mechanistic model integrates antibiotic kinetics with dynamic proteome allocation, highlighting acclimation in fluctuating environments.
Findings suggest that the benefits of anticipation in protein synthesis are amplified in environments with multiple antibiotic stresses.

Cite This Study

Cremer et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdb8e https://doi.org/10.1101/2025.07.22.666192

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