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July 25, 2025PharmaceuticalsOpen Access

Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes

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Authors

AAAniello AlfieriSFSveva Di FrancoVMVincenzo Maffei

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Overview

This review demonstrates cannabinoid receptor modulation by terpenes in chronic pain, suggesting potential therapeutic applications.

Key Points

  • Terpenes from cannabis have analgesic and anti-inflammatory effects, influencing chronic pain syndromes.
  • Compounds like myrcene and β-caryophyllene activate cannabinoid receptor type 2, impacting pain pathways.
  • The review discusses preclinical and clinical data on terpene-mediated analgesia, highlighting their biological activities.
  • Methodological variability and the need for standardized formulations limit the clinical application of terpenes.

Cite This Study

Alfieri et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce0d4https://doi.org/10.3390/ph18081100
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Also Consider

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  1. 1Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects2011 · 1,541 citations
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  3. 3Involvement of peripheral cannabinoid and opioid receptors in β ‐caryophyllene‐induced antinociception2012 · 128 citations