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July 25, 2025

Biosynthesis of the Biphenomycin Family of Potent Antibiotics

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Authors

ESElisabeth StrunkALAlfred LobertTKTatiana Khorovich

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Overview

Identifying biosynthesis of antibacterials in bacteria shows distinct enzymatic functions, suggesting pathways for drug development.

Key Points

  • Biphenomycins are novel antibiotics effective against Gram-positive bacteria with low toxicity to eukaryotic cells.
  • The study reveals the ribosomal biosynthetic pathway and key enzymatic steps involving oTyr formation and biaryl coupling.
  • Functional characterization in vivo and in vitro highlighted unique dual functions of enzymes in the biosynthesis process.
  • These findings open avenues for bioengineering strategies, enhancing antibiotic yields and addressing urgent antimicrobial needs.

Cite This Study

Strunk et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce0f7https://doi.org/10.26434/chemrxiv-2025-vkzfb
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