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May 8, 2026Angewandte ChemieOpen Access

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

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Authors

MBMichael W BrighamEHEdward S. HemsDVDaniel C L Van

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Overview

Randomized trial discovers biffamycin A as a novel antibiotic against resistant bacteria, indicating new treatment options.

Key Points

  • To discover and biosynthesize a novel glycopeptide antibiotic to combat antibiotic-resistant infections.
  • Engineered expression of a silent biosynthetic gene cluster from Streptomyces albidoflavus.
  • Utilized bioinformatics to guide the isolation and structural characterization of biffamycin A.
  • Conducted bioactivity assays against antibiotic-resistant bacterial strains.
  • Biffamycin A demonstrated significant antimycobacterial and antistaphylococcal activity.
  • Effective against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant strains.
  • Identified unique structural moieties in biffamycin A, marking it as the smallest glycopeptide antibiotic known.

Cite This Study

Brigham et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fcdbfa21ec5bbf08724https://doi.org/10.1002/ange.202511349
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