Emerging Terbinafine Resistant Trichophyton Dermatophytosis, Testing Options and Alternative Treatments: A Systematic Review

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Discussion

Systematic review finds growing terbinafine resistance in Trichophyton infections, highlighting testing gaps and alternative treatments.

Main finding shows a global increase in terbinafine-resistant trichophyton dermatophytosis cases.
Key evidence includes 94 clinical resistance cases with confirmed SQLE mutations and MIC data.
Approach involved systematic review of 34 studies, analyzing antifungal susceptibility and genetic mutations.
Significance lies in proposing routine SQLE testing to improve treatment decisions and patient outcomes.

Jegathees et al. (2025) studied this question.

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