ElectroChemputer with Integrated Monitoring for Programmable Electrochemistry

Electrochemical synthesis offers a sustainable and atom-economical alternative to conventional synthetic methods. While recent advances have enabled electrochemical discovery, the integration of real-time-control with analysis promises to allow electrochemical ‘fly-by-wire’. Herein, we present the ElectroChemputer which is a programmable, modular standard platform and enables the fully automated execution of electrochemical workflows. It uniquely integrates real-time NMR spectroscopy and electroanalytical reaction monitoring, providing both structural and quantitative insight into reaction progression. Across 170 hours runtime, the system accumulated more than 1500 coordinated unit operations and acquired > 600 cyclic voltammograms. ElectroChemputer enabled real-time stopped-flow NMR monitoring and data analysis for complex processes such as decarboxylation via alternating polarity. Furthermore, the system was shown to explore a range of transformations from nucleophilic substitutions and oxidative couplings to electrocatalytic reactions and electrodepositions, all reaction protocols were able to run in parallel, in a multistep process by introducing queues and blueprints, demonstrating the platform’s flexibility across reaction classes, electrode materials, and configurations. Through its modular architecture and real-time NMR analytics, the ElectroChemputer sets the stage for programmable, autonomous, and democratized electrochemical synthesis.