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July 25, 2025Statistical Methods in Medical Research

To what extent is response-adaptive randomization used in clinical trials? A systematic review using Cortellis Regulatory Intelligence database

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Authors

OSOleksandr SverdlovNovartis (Switzerland)JRJone RenteriaOnkologikoaKCKerstine CarterBoehringer Ingelheim (Japan)

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Overview

Systematic review identifies 39 response-adaptive randomization trials, suggesting growing acceptance in oncology and neurology.

Key Points

  • Response-adaptive randomization is increasingly utilized across various clinical phases and therapeutic areas.
  • A total of 39 trials using response-adaptive randomization were identified, with a focus on oncology and infectious diseases.
  • Out of 22 completed trials, seven reported positive outcomes that aided regulatory approval of investigational products.
  • This review establishes a baseline for understanding the application of response-adaptive randomization in clinical trials.

Cite This Study

Sverdlov et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce1c9https://doi.org/10.1177/09622802251354924
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A practical review of response-adaptive randomization: Under-explored challenges and potential directions2026
  2. 2Implementing response-adaptive randomisation in stratified rare-disease trials: Design challenges and practical solutions2025 · 2 citations
  3. 3Adaptive designs were primarily used but inadequately reported in early phase drug trials2024 · 1 citations
  4. 4Implementation of statistical features of a Bayesian two-armed responsive adaptive randomization trial with post hoc analysis of time trend drift2024
  5. 5Sample sizes for randomized controlled trials utilizing Bayesian response adaptive randomization for continuous outcomes2026