Adaptive designs were primarily used but inadequately reported in early phase drug trials

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Adaptive design increased success but does not significantly accelerate confirmatory oncology trials.2026
2. 2Adaptive trials in stroke: Current use & future directions2024
3. 3Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study2025 · 1 citations
4. 4Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps2026
5. 5To what extent is response-adaptive randomization used in clinical trials? A systematic review using Cortellis Regulatory Intelligence database2025