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April 5, 2024Open Access

Adaptive trials in stroke: Current use & future directions

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Authors

KHKathryn S. HaywardEDEmily J DaltonBCBruce Campbell

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Overview

Scoping review demonstrates the feasibility of adaptive clinical trials in stroke populations, highlighting opportunities to accelerate efficient neurological research.

Key Points

  • Adaptive clinical trials dynamically modify study conduct while preserving validity and integrity, accelerating efficient and ethical neurological evaluations.
  • Scoping review of 45 adaptive stroke trials revealed widespread feasibility, spanning acute interventions alongside rehabilitation and secondary prevention programs.
  • Highlights that adaptive trial designs support diverse research questions, though workforce readiness and regulatory considerations require dedicated planning.

Cite This Study

Hayward et al. (2024) studied this question.

synapsesocial.com/papers/68e70547b6db64358767f260https://doi.org/10.1101/2024.04.04.24305236
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Methodological Advances in the Design and Analysis of Stroke Trials2026
  2. 2Changing Landscape of Randomized Clinical Trials in Stroke: Explaining Contemporary Trial Designs and Methods2024 · 4 citations
  3. 3The Role of Adaptive and Innovative Trial Designs in Diabetes Research: A Scoping Review2025
  4. 4Adaptive designs were primarily used but inadequately reported in early phase drug trials2024 · 1 citations
  5. 5Adaptive trials and new designs2026