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April 5, 2026Revue NeurologiqueOpen Access

Adaptive trials and new designs

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Authors

CWC. WadeQueen Mary University of LondonSMS. Apap MangionQueen Mary University of LondonJCJ. ChatawayNational Institute for Health Research

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Implication

Adaptive trials improve evaluation of treatments in neurodegenerative diseases, suggesting enhanced efficiency and responsiveness to advances.

Key Points

  • Investigate the efficacy of adaptive trial designs in accelerating the development of neurological therapies.
  • Examine the implementation of multi-arm multi-stage (MAMS) designs in trials for neurodegenerative diseases.
  • Analyze interim analyses to determine when to stop ineffective arms of trials.
  • Evaluate multiple interventions concurrently against a shared control.
  • MAMS designs can speed up the evaluation of new therapies.
  • They reduce costs and participant burden in clinical trials.
  • Experience from other fields indicates their feasibility and effectiveness.

Cite This Study

Wade et al. (2026) studied this question.

synapsesocial.com/papers/69d1fb20a79560c99a0a18achttps://doi.org/10.1016/j.neurol.2026.02.155
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