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This review aims to summarize emerging methodologies that enhance the design and analysis of stroke trials.

Methodological Advances in the Design and Analysis of Stroke Trials

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This review aims to summarize emerging methodologies that enhance the design and analysis of stroke trials.
Discussed group sequential methods for interim analyses.
Outlined adaptive designs including enrichment strategies and response-adaptive randomization.
Highlighted advances in outcome assessment like ordinal analyses of the modified Rankin Scale.
Identified new statistical methods to improve the efficiency of stroke trials.
Found that patient-reported outcomes capture benefits throughout recovery.
Highlighted the importance of rigorously pre-specified protocols for valid inference.

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Review outlines advancements in stroke trial design and analysis, suggesting improvements for clinical relevance.

Lin et al. (2026) studied this question.

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