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July 25, 2025Physiological Reviews

Angiocrine and Pericrine Signaling: How Endothelial Cells and Pericytes Drive Cancer Progression and Therapy Resistance

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Authors

AJAlexander JordanQueen Mary University of LondonRDRebecca J.G. DrakeQueen Mary University of LondonKHKairbaan Hodivala‐DilkeQueen Mary University of London

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Overview

This review highlights angiocrine and pericrine signaling roles in cancer and therapy resistance, indicating novel therapeutic targets.

Key Points

  • MAIN FINDING: Endothelial and pericyte signaling are crucial in regulating cancer growth and therapy resistance.
  • KEY EVIDENCE: Research shows that these signals influence metastasis, immune responses, and tumor microenvironment dynamics.
  • APPROACH: The review summarizes existing studies on angiocrine and pericrine signaling in cancer treatment strategies.
  • SIGNIFICANCE: Understanding these interactions can lead to the development of innovative cancer therapies targeting these pathways.

Cite This Study

Jordan et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce322https://doi.org/10.1152/physrev.00046.2024
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Also Consider

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  1. 1Angiocrine factors in tumor microenvironment: bidirectional crosstalk, mechanistic insights, and therapeutic strategies2026
  2. 2The Angiocrine Niche in Cancer Therapy Responses: The Role of Vascular Endothelial Cells in Immunomodulation2026
  3. 3Endothelial cell dysfunction in cancer: a not-so-innocent bystander2024 · 2 citations
  4. 4Mechanisms of Tumor Angiogenesis and Resulting Therapy Resistance2025
  5. 5Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy2016 · 32 citations