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July 25, 2025World Journal of Gastroenterology

Gastrointestinal tract, its pathophysiology and in-vitro models: A “quick” reference guide to translational studies

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Authors

KSKristijan SkokBVBoštjan ViharUMUroš Maver

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Overview

Review explores limitations of cell cultures and highlights three-dimensional and microfluidic systems, suggesting better replication of GI tract.

Key Points

  • The gastrointestinal tract is vital for digestion and absorption, influenced by a diverse microbial ecosystem.
  • Traditional two-dimensional cell cultures do not adequately capture the physiological complexity of the GI tract.
  • Emerging three-dimensional and microfluidic systems enhance the relevance of in-vitro models for personalized medicine.
  • Advanced techniques like bioprinting enable the creation of complex tissue models simulating critical GI processes.

Cite This Study

Skok et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce32ahttps://doi.org/10.3748/wjg.v31.i28.108297
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