Systematic review highlights the development of in vitro gut microbiota models, indicating the need for standardization in biomedical applications.
Key Points
The aim is to review the recent developments of in vitro gut microbiota models and their relevance in biomedical research and treatment of digestive diseases.
Conducted a systematic review based on PRISMA guidelines.
Examined various in vitro models including batch and dynamic fermentation models.
Evaluated advanced technologies like organoids and gut-on-a-chip.
Summarized advanced in vitro approaches for studying gut microbiota.
Identified advantages and limitations of each model.
Emphasized the need for standardization in model development and regulatory frameworks.