July 25, 2025Open Access

One-Pot Synthesis of Thiochromones

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The one-pot synthesis of thiochromones achieves good yields, reaching up to 81% with various substrates.
By combining two transformations in a single reaction, this method eliminates intermediate purification steps.
Thiochromones have significant biological activities, including antioxidant and anticancer properties.
This efficient synthetic approach enhances access to a wider range of thiochromones using readily available thiophenols.

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One-pot synthesis generates thiochromones from 3-(arylthiol)propanoic acid, suggesting reduced waste and cost benefits.

Simpkins et al. (2025) studied this question.

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