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July 26, 2025CellsOpen Access

The Role of Lactate in Immune Regulation: A Metabolic Rheostat via Transporters, Receptors, and Epigenetic Modifiers

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Authors

ECEun Jung ChoiYJYoon Young JangECEun Joo Choi

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Overview

Review shows lactate's dual role in inflammation and immunity in various diseases, indicating its potential in immunotherapy.

Key Points

  • MAIN FINDING: Lactate acts as an immunometabolic regulator, influencing immune responses in health and disease.
  • KEY EVIDENCE: The review covers mechanisms of lactate accumulation in conditions like cancer, sepsis, and diabetes.
  • APPROACH: Integrated mechanisms of lactate modulation via transporters, receptors, and epigenetic modifications were examined.
  • SIGNIFICANCE: Understanding lactate's role can guide the design of therapies that modulate immune responses effectively.

Cite This Study

Choi et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce581https://doi.org/10.3390/cells14141096
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