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June 11, 2026Science ResearchOpen Access

Metabolic Function of Lactate and the Regulation and Biological Functions of Lactylation Modification

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Authors

LHLinyue HouBSBaosheng SunJSJinhui Sun

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Overview

Systematic review highlights lactate's role in metabolism and lactylation's epigenetic functions, suggesting therapeutic potential.

Key Points

  • This review aims to explore the metabolic functions of lactate and the regulatory roles of lactylation modifications in biological processes.
  • Systematic review of lactate production, transport, and metabolic functions
  • Discussion of the 'writers-erasers-readers' regulatory network of lactylation
  • Analysis of lactate's role in various biological processes like immune regulation and inflammation
  • Lactylation modifies histone and non-histone proteins, influencing gene transcription and immune responses
  • Lactate metabolism targeting shows therapeutic promise in tumors and metabolic disorders
  • Lactylation reveals differences in modification mechanisms and site specificity, linking metabolism with epigenetic regulation

Cite This Study

Hou et al. (2026) studied this question.

synapsesocial.com/papers/6a2a52ae80c8f91e7f39e9dehttps://doi.org/10.11648/j.sr.20261403.11
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactylation formation, gene regulation, biological functions, and clinical relevance.2025
  2. 2Lactylation: the novel histone modification influence on gene expression, protein function, and disease2024 · 174 citations
  3. 3Lactate: elucidating its indispensable role in human health2026
  4. 4Lactate and lactylation: mechanisms, function, diseases, and therapeutic targets2026 · 2 citations
  5. 5Progress of Research on the Metabolic Regulation of Lactylation in Muscle Tissues and Its Disease Associations2026 · 1 citations