Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2025Open Access

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

View Full Paper
Ask AI
Bookmark
Share

Authors

GSGiulia SilvaniCKChantal KopeckySRS. Romanazzo

Discussion

Loading...

Member takes

Overview

Research demonstrates microcapillary constriction increases tumorigenic properties in melanoma cells, suggesting PIEZO1 plays a crucial role.

Key Points

  • Constriction in microcapillaries triggers melanoma cells to adopt tumorigenic cancer stem cell-like traits.
  • Using a microfluidic device, the study revealed that narrow channels caused significant cell and nuclear deformation.
  • Increased regulation of transcripts linked to metabolic reprogramming occurred soon after microcapillary transit.
  • Both pharmacological modulation of PIEZO1 and its deletion significantly impacted the stem cell-like state of the cancer cells.

Cite This Study

Silvani et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce5fchttps://doi.org/10.1101/2025.07.22.666218
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells2024 · 8 citations
  2. 2Orai1 promotes tumor progression by enhancing cancer stemness <i>via</i> NFAT signaling in oral/oropharyngeal squamous cell carcinoma2016 · 57 citations
  3. 3Piezo1 Channels Are Inherently Mechanosensitive2016 · 562 citations
  4. 4Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration2022 · 34 citations
  5. 5Identification of Pancreatic Cancer Stem Cells2007 · 3,385 citations