Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 3, 2025

TRPM7 Annexin A1 Mechanosensitive Pathway Drives Capillary Infiltration by Circulating Tumor Cells

View Full Paper
Ask AI
Bookmark
Share

Authors

LLLanfeng LiangZZZhifeng ZhaoJCJonathan Wei Bao Chua

Discussion

Loading...

Member takes

Overview

Microfluidic experiments reveal TRPM7-Annexin A1 pathway assists cell motility under fluid shear stress, indicating new therapeutic targets.

Key Points

  • MAIN FINDING: The TRPM7-Annexin A1 pathway is crucial for circulating tumor cells to navigate through capillaries.
  • KEY EVIDENCE: Only breast cancer cells with high metastatic potential migrated effectively under fluid shear stress conditions.
  • APPROACH: Microfluidics mimicking microcirculatory dynamics revealed how CTCs adapt to mechanical challenges during transit.
  • SIGNIFICANCE: Targeting the TRPM7 pathway could offer new options to inhibit metastatic spread of cancer cells.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d065dhttps://doi.org/10.1101/2025.08.01.668151
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insights into the mechanobiology of cancer metastasis via microfluidic technologies2024 · 17 citations
  2. 2Mouse 4T1 Breast Tumor Model2000 · 932 citations
  3. 3Therapeutic potential of Fingolimod in triple negative breast cancer preclinical models2020 · 26 citations
  4. 4Extracellular fluid viscosity enhances cell migration and cancer dissemination2022 · 434 citations