Clinical Outcome of Intra-Articular Injection of Platelet Rich Plasma in Osteoarthritis Knee

Abstract Introduction: Osteoarthritis (OA) of the knee is a prevalent condition that significantly impacts the quality of life for millions of individuals worldwide. As a leading cause of disability, its effective management is crucial. Intra-articular injections of platelet-rich plasma (PRP) have gained attention as a potential treatment, offering a biologic approach to enhance cartilage repair and reduce inflammation. This study evaluates the clinical efficacy of PRP injections in knee OA management, focusing on pain relief and functional improvement. Methods: The study involved 59 patients (61 knees) diagnosed with KL grade II and III knee OA who received PRP injections. Patients were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analogue Scale (VAS) scores. Evaluations were conducted at baseline and two, four, and six months post-injection to assess pain relief and functional improvement. Results: Significant reductions in VAS pain scores and WOMAC functional disability scores were observed following PRP therapy. Pain and stiffness improved notably within the first few months post-treatment, with KL grade II patients experiencing better outcomes than KL grade III patients. The study confirmed PRP’s effectiveness as a non-surgical intervention, with no severe adverse effects reported. Conclusion: PRP injections appear to be a viable regenerative treatment for knee OA, offering meaningful pain reduction and mobility enhancement. Although the initial benefits are significant, long-term efficacy remains uncertain, warranting further research. Establishing optimal patient selection criteria and repeated dosing protocols may enhance future outcomes.