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July 28, 2025Open Access

Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice

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Authors

BBBudhaditya BasuNBNicole M. BreeseSLStefania Lombardi

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Overview

Experiment revealed deficits in spatial memory due to polychlorinated biphenyls, indicating impacts on cognition and brain integrity.

Key Points

  • Mice exposed to polychlorinated biphenyls showed significant deficits in long-term spatial memory.
  • Spatial transcriptomics analysis identified gene expression changes in key brain regions affected by PCB exposure.
  • Disruption of tight junction proteins was observed, affecting the integrity of the blood-brain barrier in exposed mice.
  • These findings suggest a link between environmental toxicants and cognitive decline, highlighting PCB risks.

Cite This Study

Basu et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce83ehttps://doi.org/10.1101/2025.07.24.665575
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