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July 8, 2026NeuroToxicologyOpen Access

Long-term effects of polychlorinated biphenyls: Neuropsychological outcomes of a longitudinal cohort study

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Authors

JCJulia Luka CrombergTSThomas SchettgenKWKlaus Willmes

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Overview

Longitudinal cohort study shows that PCB exposure leads to lasting cognitive impairments, suggesting a mechanism of neurobiological damage.

Key Points

  • This study aims to examine the long-term neuropsychological effects of polychlorinated biphenyl (PCB) exposure in occupationally exposed individuals.
  • Analyzed neuropsychological outcomes from five assessments of the HELPcB cohort.
  • Investigated the relationship between plasma PCB levels and cognitive functions using Linear Mixed Models.
  • Differentiated chronic effects of accumulated PCB body burden from acute fluctuations in exposure.
  • Chronic PCB exposure negatively affected verbal fluency, sensorimotor processing, and alertness.
  • Acute fluctuations in PCB levels did not show a statistically significant impact on cognitive performance.
  • Long-term neurobiological damage was indicated as a potential mechanism disrupting cognitive function.

Cite This Study

Cromberg et al. (2026) studied this question.

synapsesocial.com/papers/6a6aed2b79eb7ca170244751https://doi.org/10.1016/j.neuro.2026.103507
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Also Consider

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  1. 1Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice2026 · 2 citations
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