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February 14, 2026AntioxidantsOpen Access

Polychlorinated Biphenyls, Oxidative Stress, and Brain Health: Mechanistic Links to Neurodegenerative and Neurodevelopmental Diseases

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Authors

AMAurelio MinutiAFAlessia FloramoVAVeronica Argento

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Overview

This review highlights the links between PCB exposure and neurodevelopmental risks, emphasizing oxidative stress implications.

Key Points

  • The aim is to explore the mechanisms by which PCBs affect brain health and contribute to neurodegenerative and neurodevelopmental diseases.
  • Review of experimental and epidemiological studies on PCB exposure effects on neurological health.
  • Analysis of cellular mechanisms related to oxidative stress and neuronal function disruption.
  • Discussion of neuroprotective antioxidant strategies for mitigating PCB-related health risks.
  • PCB exposure is linked to impaired cognitive and motor functions and increased risks of neurodevelopmental disorders.
  • Chronic PCB exposure in adulthood associates with neurodegenerative diseases.
  • Mechanisms identified include oxidative stress, calcium dysregulation, and synaptic dysfunction, all contributing to neuronal loss.

Cite This Study

Minuti et al. (2026) studied this question.

synapsesocial.com/papers/699011932ccff479cfe585dahttps://doi.org/10.3390/antiox15020242
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PCB 118 Exposure Modulates Chromatin Organization, Ribosome Biogenesis, and Autophagy-Related Pathways in Neuron-like: A Transcriptomic Analysis2026
  2. 2Molecular insights into PCB neurotoxicity: Comparing transcriptomic responses across dopaminergic neurons, population blood cells, and Parkinson's disease pathology2024 · 14 citations
  3. 3Long-term effects of polychlorinated biphenyls: Neuropsychological outcomes of a longitudinal cohort study2026
  4. 4Neurotoxicity mechanism of polychlorinated biphenyl mediated by dopaminergic system2026 · 1 citations
  5. 5Cognitive effects of early life exposure to PCBs: Sex-specific behavioral, hormonal and neuromolecular mechanisms involving the brain dopamine system2024