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July 28, 2025

Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF4

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Authors

JXJihao XuQTQiudi TuLZLi Zhao

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Overview

Experimental study demonstrates AS-IV improves myocardial injury in uremic mice by regulating autophagy, implicating ATF4 and the PI3K pathway.

Key Points

  • AS-IV treatment improved cardiac function and reduced uremia-related cardiomyocyte apoptosis in mouse models.
  • The study employed various techniques, including echocardiography and flow cytometry, to assess myocardial injury and autophagy.
  • Inhibition of ATF4 expression decreased cardiomyocyte apoptosis, highlighting its protective role against myocardial injury.
  • AS-IV was shown to activate the PI3K pathway, suggesting its involvement in autophagy regulation during treatment.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce9b0https://doi.org/10.21203/rs.3.rs-7145726/v1
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