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December 8, 2025Scientific ReportsOpen Access

Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF4

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Authors

QTQiudi TuLZLi ZhaoXYXianyun Ye

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Overview

Observational analysis revealed autophagy inhibition improves myocardial injury in uremia, suggesting ATF4 is a key target.

Key Points

  • Myocardial injury was notably reduced by inhibiting ATF4, impacting autophagy in uremic conditions.
  • Key metric includes important modulation of autophagy linked to ATF4 levels post-Astragaloside IV treatment.
  • Analysis focused on the role of the PI3K pathway in regulating autophagy response to AS-IV treatment.
  • These findings may highlight potential therapeutic targets for managing uremia-related cardiac dysfunction.

Cite This Study

Tu et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c54fhttps://doi.org/10.1038/s41598-025-30374-x
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