Molecular Mechanisms Underlying Inflammation in Early-Onset Neonatal Sepsis: A Systematic Review of Human Studies

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Systematic review reveals interactions of inflammation and immune responses in early-onset neonatal sepsis, highlighting new diagnostic strategies.

Early-onset neonatal sepsis significantly contributes to neonatal morbidity and mortality, underlining the need for improved detection methods.
Pathogen-induced inflammation involves Toll-like receptors and pro-inflammatory cytokines like IL-6, which impact immune responses.
The study reviews original research to analyze molecular mechanisms of immune dysregulation related to early-onset neonatal sepsis.
Understanding these mechanisms aids in developing novel diagnostic and therapeutic strategies for improving neonatal health outcomes.

Vulcănescu et al. (2025) studied this question.

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Systematic review reveals interactions of inflammation and immune responses in early-onset neonatal sepsis, highlighting new diagnostic strategies.