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July 29, 2025Journal of Translational MedicineOpen Access

Discordant CAR-T cell signaling: implications of divergence from physiological T cell activation

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Authors

PGPablo Gonzalez-GarciaNMNoelia MoaresISIsabel Serrano-García

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Overview

Review highlights how discordant signaling in CAR-T cells affects their effectiveness in cancer therapy, suggesting implications for future designs.

Key Points

  • CAR-T cell therapy shows promise but may not fully replicate physiological T cell receptor activation.
  • Differences in CAR-T cell activation occur early during the immune synapse formation, impacting their efficacy.
  • The review emphasizes impaired signaling events as a key factor in the limitations of CAR-T cells in treating tumors.
  • Understanding the signaling divergency could lead to enhanced CAR-T cell therapies for better patient outcomes.

Cite This Study

Gonzalez-Garcia et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cec13https://doi.org/10.1186/s12967-025-06857-w
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