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July 30, 2025AntioxidantsOpen Access

Expression of Free Radicals and Reactive Oxygen Species in Endometriosis: Current Knowledge and Its Implications

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Authors

JLJeongmin LeeSYSeung Geun YeoJLJae Min Lee

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Overview

This review finds a significant link between reactive oxygen species and endometriosis pathogenesis, indicating potential antioxidant therapies.

Key Points

  • Elevated levels of reactive oxygen species are significantly involved in the pathogenesis of endometriosis.
  • The review assessed 30 papers, with 28 showing a clear link between free radicals and infertility in endometriosis.
  • Hydrogen peroxide and lipid peroxides are among the most studied reactive oxygen species in relation to endometriosis.
  • Targeting antioxidant therapies, including vitamins C and E, may provide potential treatments for endometriosis-related symptoms.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee28https://doi.org/10.3390/antiox14070877
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants2024 · 31 citations
  2. 21H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis2013 · 81 citations
  3. 3Epigenetics, Oxidative Stress, and the Microbiome in Endometriosis: Toward an Integrated Mechanistic Framework for Precision Medicine2026 · 1 citations
  4. 4Mechanisms and clinical implications of oxidative stress-mediated endometrial receptivity impairment in polycystic ovary syndrome2026
  5. 5FOS and Other Genes Linked to Oxidative Stress Are Upregulated in Women Suffering from Endometriosis and Might Negatively Impact the Oocyte Developmental Competence During ICSI2026