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January 1, 2013BioMed Research InternationalOpen Access

1H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis

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Authors

SJSaikat Kumar JanaMDMainak DuttaMJMamata Joshi

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Overview

Metabolomic analysis reveals metabolic dysregulation and oxidative stress markers in endometriosis, highlighting mitochondrial defects as potential drivers.

Key Points

  • To identify metabolite dysregulation and investigate its relationship with oxidative stress in women with endometriosis using targeted proton nuclear magnetic resonance spectroscopy.
  • Targeted metabolite profiling was conducted using proton nuclear magnetic resonance (1H NMR) spectroscopy on samples from women with endometriosis.
  • Multivariate statistical modeling was performed via partial least squares discriminant analysis (PLS-DA) alongside quantification of oxidative stress markers and antioxidant enzymes.
  • The PLS-DA model classified endometriosis patients with 92.83% sensitivity, 100% specificity, and an overall classification rate of 96.4%.
  • Patients exhibited elevated levels of citrate, succinate, glucose metabolism markers, reactive oxygen species, lipid peroxidation, and advanced oxidation protein products.
  • Endometriosis was accompanied by reduced total antioxidant capacity and lower levels of superoxide dismutase, catalase, and glutathione.

Cite This Study

Jana et al. (2013) studied this question.

synapsesocial.com/papers/6a95b31847067fbffd7ea79bhttps://doi.org/10.1155/2013/329058
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Also Consider

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