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September 19, 2025International Journal of Molecular SciencesOpen Access

Exploring Oxidative Stress in Different Endometriosis Phenoptypes: Insights from Ovarian and Systemic Perspectives by the Study of SIRT3

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Authors

AGAnna GodayLVLaura Valls‐RocaMMMarta Méndez

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Overview

Longitudinal study compares oxidative stress in endometriosis patients, revealing SIRT3's potential as a therapeutic target.

Key Points

  • Higher SIRT3 levels were found in patients with deep endometriosis, indicating its role in disease severity.
  • SIRT3's regulation of oxidative stress suggests it may be a viable therapeutic target for managing endometriosis.
  • Infertility affects nearly 50% of endometriosis patients, pointing to a significant burden on women's health.
  • No diagnostic biomarkers currently exist for endometriosis, highlighting a key area for future research.

Cite This Study

Goday et al. (2025) studied this question.

synapsesocial.com/papers/68d464ff31b076d99fa64b58https://doi.org/10.3390/ijms26189110
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FOS and Other Genes Linked to Oxidative Stress Are Upregulated in Women Suffering from Endometriosis and Might Negatively Impact the Oocyte Developmental Competence During ICSI2026
  2. 2SIRT3 protects endometrial receptivity in patients with polycystic ovary syndrome2024 · 2 citations
  3. 31H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis2013 · 81 citations
  4. 4Systemic Oxidative Stress Markers in Endometriosis: Elevated Advanced Glycation End Products and Sestrin 2 in Women with Ovarian Endometrioma2026 · 1 citations
  5. 5Epigenetics, Oxidative Stress, and the Microbiome in Endometriosis: Toward an Integrated Mechanistic Framework for Precision Medicine2026 · 1 citations