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This study aims to investigate serum levels of oxidative stress markers in women with ovarian endometrioma.

February 12, 2026BiomedicinesOpen Access

Systemic Oxidative Stress Markers in Endometriosis: Elevated Advanced Glycation End Products and Sestrin 2 in Women with Ovarian Endometrioma

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Case-control study evaluates elevated biomarkers of oxidative stress in women with ovarian endometrioma, indicating potential diagnostic utility.

This study aims to investigate serum levels of oxidative stress markers in women with ovarian endometrioma.
Prospective case-control design
80 reproductive-aged women enrolled (37 with ovarian endometrioma, 43 controls)
Serum concentrations of AGEs and SESN2 measured using enzyme-linked immunosorbent assay
Receiver operating characteristic analysis to assess diagnostic performance.
Circulating AGEs significantly higher in patients (110.11 ng/mL) than controls (91.70 ng/mL; p = 0.007)
SESN2 levels also significantly elevated (9.32 ng/mL vs. 5.57 ng/mL; p < 0.001)
SESN2 showed high diagnostic accuracy (AUC = 0.893) with 87.39% sensitivity and 86.05% specificity.

Selçuki et al. (2026) studied this question.

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Case-control study evaluates elevated biomarkers of oxidative stress in women with ovarian endometrioma, indicating potential diagnostic utility.