What question did this study set out to answer?

To determine whether markers of oxidative stress and DNA damage are elevated in the primordial follicles of patients with endometriomas compared to age-matched benign controls.

August 14, 2026

Endometriosis and ovarian aging: a pilot study exploring oxidative stress and DNA damage markers.

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Authors

LKLuce A. KassiWomen & Infants Hospital of Rhode Island SKSanjana KondaBrown University JOJoyce OuBrown University

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Implication

Retrospective cohort study reveals elevated DNA damage markers in primordial follicles of patients with endometriomas, suggesting impaired egg quality.

Key Points

To determine whether markers of oxidative stress and DNA damage are elevated in the primordial follicles of patients with endometriomas compared to age-matched benign controls.
Retrospective pilot cohort study analyzing ovarian tissue from patients undergoing salpingo-oophorectomy for symptomatic endometriomas versus benign gynecologic control conditions.
Immunohistochemistry was utilized to evaluate percent positivity in primordial follicles for 4-hydroxy-2-nonenal (4-HNE), 8-oxoguanine (8-Oxo), and phosphorylated H2AX (γH2AX).
Primordial follicles in the endometrioma group showed a statistically significant increase in γH2AX positivity compared to controls (63.6% vs. 50.1%, p = 0.033).
Markers 8-Oxo (67.5% vs. 55.8%, p = 0.070) and 4-HNE (65.1% vs. 61.8%, p = 0.168) were elevated in endometrioma tissue but did not achieve statistical significance.

Cite This Study

Kassi et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec6c6b70b84ec8b912eb0 https://doi.org/10.1007/s10815-026-03990-3

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Implication

Retrospective cohort study reveals elevated DNA damage markers in primordial follicles of patients with endometriomas, suggesting impaired egg quality.

Endometriosis and ovarian aging: a pilot study exploring oxidative stress and DNA damage markers.

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Implication

Key Points

Cite This Study

Endometriosis and ovarian aging: a pilot study exploring oxidative stress and DNA damage markers.

Discussion

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Implication

Key Points

Cite This Study

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