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January 24, 2023Journal of Clinical MedicineOpen Access

Gas Chromatography–Mass Spectrometry (GC–MS) Metabolites Analysis in Endometriosis Patients: A Prospective Observational Translational Study

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Authors

SAStefano AngioniFCFrancesca CongiuSVSalvatore Giovanni Vitale

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Overview

Prospective observational study reveals distinct serum metabolic shifts in women with endometriosis, highlighting potential biomarkers for earlier disease diagnosis.

Key Points

  • To identify metabolic alterations in the serum of patients with endometriosis using gas chromatography–mass spectrometry in order to discover diagnostic biomarkers and elucidate disease pathophysiology.
  • Conducted a prospective translational study analyzing serum samples from 22 patients with symptomatic endometriosis and 10 control individuals without endometriosis.
  • Performed gas chromatography–mass spectrometry (GC–MS) profiling followed by univariate, multivariate statistical, and biological pathway analyses.
  • Serum concentrations of threonic acid, 3-hydroxybutyric acid, and proline were significantly increased, while alanine and valine were significantly decreased in patients with endometriosis (p = 0.003).
  • Biological pathway analysis demonstrated significant alterations in the synthesis and degradation of ketone bodies as well as the biosynthesis of phenylalanine, tyrosine, and tryptophan.

Cite This Study

Angioni et al. (2023) studied this question.

synapsesocial.com/papers/6a79e2cf4353fbf060020f1ehttps://doi.org/10.3390/jcm12030922
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrating Metabolic and MicroRNA Profiling to the Diagnostics of Endometriosis: A Pilot Study2026 · 1 citations
  2. 2Exploring the Urine Metabolome in Endometriosis and Its Potential for Noninvasive Diagnosis2026
  3. 3Biochemical Profiling of Inflammatory and Metabolic Markers in Reproductive-Age Women with Endometriosis2023 · 1 citations
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  5. 51H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis2013 · 81 citations