Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 30, 2025BiomedicinesOpen Access

Revolutionizing Allogeneic Graft Tolerance Through Chimeric Antigen Receptor-T Regulatory Cells

View Full Paper
Ask AI
Bookmark
Share

Authors

ACAlvin Man Lung ChanRSRajalingham SakthiswaryYLYogeswaran Lokanathan

Discussion

Loading...

Member takes

Overview

Systematic review demonstrates CAR-T regulatory cells improve graft survival in transplant models, suggesting new treatment avenues for graft rejection.

Key Points

  • CAR-T regulatory cells show greater graft protection than unmodified Tregs in transplant models.
  • HLA-A2-specific CAR-Tregs significantly improve graft survival and reduce inflammatory cytokines.
  • Including CD28 as a co-stimulatory domain enhances Treg function and stability.
  • Challenges like Treg exhaustion and reduced persistence remain, needing further optimization for clinical use.

Cite This Study

Chan et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee43https://doi.org/10.3390/biomedicines13071757
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Chimeric Antigen Receptor Regulatory T Cells in Promoting Immune Tolerance in Solid Organ Transplantation: <i>Mechanisms and Therapeutic Potential</i>2026
  2. 2Bioengineered T Cell Therapies for Precision Immunotherapy in Renal Transplantation, Autoimmune Relapse, and Sensitization2025 · 2 citations
  3. 3Efficacy and limitations of combined A2.CAR Treg and anti-CD154 therapy in a mouse model of haplo-mismatched heart transplantation2024
  4. 4Preclinical and Clinical Developments in Treg Therapy for Heart Transplantation: Critical Assessment and Translational Challenges2026 · 2 citations
  5. 5High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells2024 · 1 citations