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August 11, 2026Saudi Medical JournalOpen Access

The Role of Chimeric Antigen Receptor Regulatory T Cells in Promoting Immune Tolerance in Solid Organ Transplantation: Mechanisms and Therapeutic Potential

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Authors

MAMaher S. Alwethaynani

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Overview

This review discusses how CAR Treg cells enhance transplant tolerance while reducing immunosuppressant reliance.

Key Points

  • This review aims to highlight the roles of chimeric antigen receptor regulatory T cells in achieving immune tolerance in solid organ transplantation.
  • Reviewing the implications of immunosuppression in solid organ transplantation
  • Discussing CAR and CAR Treg biology and mechanisms of Treg-mediated tolerance
  • Evaluating clinical trials and optimization strategies for CAR Treg therapies
  • CAR Tregs have the potential to enhance graft survival and quality of life by minimizing immunosuppressant-related issues.
  • Challenges exist in fully understanding Treg biology and issues surrounding CAR Treg manufacturing.
  • Future directions include addressing the technical barriers for effective CAR Treg therapies in solid organ transplantation.

Cite This Study

Maher S. Alwethaynani (2026) studied this question.

synapsesocial.com/papers/6a7ace1a3401087f2249dcc2https://doi.org/10.15537/1658-3175.8836
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Revolutionizing Allogeneic Graft Tolerance Through Chimeric Antigen Receptor-T Regulatory Cells2025 · 6 citations
  2. 2Bioengineered T Cell Therapies for Precision Immunotherapy in Renal Transplantation, Autoimmune Relapse, and Sensitization2025 · 2 citations
  3. 3Regulatory T cell therapy in solid organ transplantation: clinical applications and laboratory monitoring strategies.2025
  4. 4Preclinical and Clinical Developments in Treg Therapy for Heart Transplantation: Critical Assessment and Translational Challenges2026 · 2 citations
  5. 5Graft-Specific Regulatory T Cells for Long-Lasting, Local Tolerance Induction2024 · 7 citations