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July 30, 2025Physiological Reviews

Metabolic adaptations in cancer progression

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Authors

YPYiming Peng‐WinklerSFSarah‐Maria Fendt

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Overview

Review examines metabolic alterations during cancer metastasis, highlighting potential therapeutic targets in different microenvironments.

Key Points

  • Cancer cells undergo unique metabolic adaptations as they spread to distant sites, impacting treatment outcomes.
  • The review details specific metabolic shifts associated with each stage of metastasis and their significance.
  • Understanding the microenvironment is crucial for identifying therapeutic targets within metastatic tumors.
  • Challenges in targeting metabolic pathways in cancer therapy are pivotal for future treatment strategies.

Cite This Study

Peng‐Winkler et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee72https://doi.org/10.1152/physrev.00037.2024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Adaptations in Cancer Progression: Optimization Strategies and Therapeutic Targets2025 · 12 citations
  2. 2Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism2025 · 15 citations
  3. 3Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship2026
  4. 4Metabolic Rewiring During Metastasis: The Interplay Between the Environment and the Host2024 · 3 citations
  5. 5Cancer Metabolism and Its Historical & Molecular Foundations: An Overview2026 · 4 citations