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The aim is to explore the historical and molecular foundations of cancer metabolism and its therapeutic implications.

March 3, 2026Open Access

Cancer Metabolism and Its Historical & Molecular Foundations: An Overview

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This overview examines cancer metabolism's historical foundations and molecular adaptations, highlighting therapeutic implications.

The aim is to explore the historical and molecular foundations of cancer metabolism and its therapeutic implications.
Reviewed historical and current literature on cancer metabolism.
Analyzed the role of metabolic pathways like glycolysis and glutamine metabolism.
Discussed the impact of the tumor microenvironment on metabolic adaptations.
Identified emerging strategies for precision treatments in oncology.
Cancer metabolism involves complex reprogramming driven by oncogenes and tumor suppressor genes.
Key adaptations include metabolic plasticity, oncometabolite-driven epigenetic changes, and immune crosstalk.
Therapeutic strategies, including dietary interventions and metabolic inhibitors, show promise but face challenges.
Clinical translation is limited by metabolic redundancy, microenvironmental buffering, and patient diversity.

Rami A. Al-Horani (2026) studied this question.

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