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June 17, 2026Experimental Hematology and OncologyOpen Access

Rewiring tumor metabolism: heterogeneity, oncometabolites, and adaptive plasticity

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Authors

JYJianqiang YangEmory UniversityCZCatherine C. ZhouGeorgia Institute of TechnologySKSoumya Vijaya KumarEmory University

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Implication

Review examines metabolic heterogeneity in tumors and its implications for therapy resistance, suggesting novel treatment strategies.

Key Points

  • This review aims to explore the dynamics of tumor metabolism and its implications for cancer therapy and resistance.
  • Discusses the origins of metabolic heterogeneity and adaptive plasticity in tumors.
  • Examines strategies to combat therapeutic resistance through metabolic targeting.
  • Highlights the importance of patient stratification based on metabolic profiles.
  • Identifies key metabolic pathways like glycolysis and oxidative phosphorylation as cancer adaptations.
  • Finds that metabolic heterogeneity promotes immune evasion and therapy tolerance.
  • Suggests potential for novel therapeutic vulnerabilities based on metabolic complexities.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a3239c2d50b63ecad20517ahttps://doi.org/10.1186/s40164-026-00795-z
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