July 30, 2025Open Access

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms

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Targeted disruption of phage droplets effectively abolishes antibiotic tolerance in bacterial biofilms.
Nanobodies designed to bind the Pf4 phage significantly promoted antibiotic diffusion into Pseudomonas aeruginosa.
Liquid crystalline droplets associated with phage in biofilms exhibit unique biophysical properties that enable antibiotic protection.
This approach highlights the potential for novel interventions targeting biophysical mechanisms in treating pathogenic biofilms.

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Targeted phage binders disrupt biofilm formation in Pseudomonas aeruginosa, suggesting new strategies for overcoming antibiotic tolerance.

Tarafder et al. (2025) studied this question.

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Targeted phage binders disrupt biofilm formation in Pseudomonas aeruginosa, suggesting new strategies for overcoming antibiotic tolerance.